Bone has a remarkable endogenous regenerative capacity that enables scarless healing
and restoration of its prior mechanical function, even under challenging conditions such as …

With the aging of population and the rapid improvement of public health and medical level in
recent years, people have had an increasing demand for orthopedic implants. However …

Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …

Osteoimmunology is at full display during endosseous implant osseointegration. Bone
formation, maintenance and resorption at the implant surface is a result of bidirectional and …

Objectives Bone defects caused by diseases and trauma are usually accompanied by
inflammation, and the implantation of biomaterials as a common repair method has also …

Osteoporosis has been classically considered a comorbidity of rheumatoid arthritis (RA).
However, recent advances in the pathogenesis of osteoporosis in RA have shown a close …

Abstract More than 2.1 million age-related fractures occur in the United States annually,
resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of …

Monocytes and macrophages are innate immune cells with diverse functions ranging from
phagocytosis of microorganisms to forming a bridge with the adaptive immune system. A …

Coupling between angiogenesis and osteogenesis has an important role in both normal
bone injury repair and successful application of tissue‐engineered bone for bone defect …

Abstract Treatment of large bone defects represents a great challenge in orthopedic and
craniomaxillofacial surgery. Traditional strategies in bone tissue engineering have focused …