Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …

Multidrug resistant (MDR) bacteria are a global threat with many common infections
becoming increasingly difficult to eliminate. While significant effort has gone into the …

Necrotic cell death during Mycobacterium tuberculosis (Mtb) infection is considered host
detrimental since it facilitates mycobacterial spread. Ferroptosis is a type of regulated …

We report the discovery of a series of new drug leads that have potent activity against
Mycobacterium tuberculosis as well as against other bacteria, fungi, and a malaria parasite …

The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …

Tuberculosis (TB) remains a major health problem worldwide. The infectious agent,
Mycobacterium tuberculosis, has a unique ability to survive within the host, alternating …

The indispensable requirement for metals in life processes has led to the evolution of
sophisticated mechanisms that allow organisms to maintain dynamic equilibria of these ions …

Drug discovery aimed at the efficient eradication of life‐threatening bacterial infections,
especially in light of the emergence of multi‐drug resistance of pathogenic bacteria, has …

Tuberculosis remains an important cause of morbidity and mortality throughout the world,
amplified by the expansion of antibiotic resistance. Increasing active efflux of the antibiotic is …

Iron is an essential element to most life forms including mycobacterial species. However, in
the oxidative atmosphere iron exists as insoluble salts. Free and soluble iron ions are scarce …