From entry to egress: strategic exploitation of the cellular processes by HIV-1
HIV-1 employs a rich arsenal of viral factors throughout its life cycle and co-opts intracellular
trafficking pathways. This exquisitely coordinated process requires precise manipulation of …
trafficking pathways. This exquisitely coordinated process requires precise manipulation of …
[HTML][HTML] A comprehensive perspective of traditional Arabic or Islamic medicinal plants as an adjuvant therapy against COVID-19
COVID-19 is a pulmonary disease caused by SARS-CoV-2. More than 200 million
individuals are infected by this globally. Pyrexia, coughing, shortness of breath, headaches …
individuals are infected by this globally. Pyrexia, coughing, shortness of breath, headaches …
[HTML][HTML] HIV-1 Reverse Transcriptase/Integrase dual inhibitors: A review of recent advances and structure-activity relationship studies
M Mahboubi-Rabbani, M Abbasi… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
The significant threat to humanity is HIV infection, and it is uncertain whether a definitive
treatment or a safe HIV vaccine is. HIV-1 is continually evolving and resistant to commonly …
treatment or a safe HIV vaccine is. HIV-1 is continually evolving and resistant to commonly …
[HTML][HTML] Genome sequence analysis suggests coevolution of the DIS, SD, and Psi hairpins in HIV-1 genomes
HIV-1 RNA dimerization is a critical step in viral life cycle. It is a prerequisite for genome
packaging and plays an important role in reverse transcription and recombination …
packaging and plays an important role in reverse transcription and recombination …
Synthesis of C3, C6-Diaryl 7-Azaindoles via One-Pot Suzuki–Miyaura Cross-Coupling Reaction and Evaluation of Their HIV-1 Integrase Inhibitory Activity
There is a continuing demand of new inhibitors of HIV-1 Integrase (HIV-1 IN) due to
mutations of HIV-1. This study aims to develop the synthesis of 3, 6-diaryl 7-azaindoles and …
mutations of HIV-1. This study aims to develop the synthesis of 3, 6-diaryl 7-azaindoles and …
The cellular SFPQ protein as a positive factor in the HIV-1 integration
Т Kikhai, Y Agapkina, M Silkina, T Prikazchikova… - Biochimie, 2024 - Elsevier
The cellular SFPQ protein is involved in several stages of the HIV-1 life cycle, but the
detailed mechanism of its involvement is not yet fully understood. Here, the role of SFPQ in …
detailed mechanism of its involvement is not yet fully understood. Here, the role of SFPQ in …
SFPQ and NONO Proteins and long non-coding NEAT1 RNA: cellular functions and role in the HIV-1 life cycle
OA Shadrina, TF Kikhay, YY Agapkina, MB Gottikh - Molecular Biology, 2022 - Springer
About 20 years ago, large RNA–protein complexes called paraspeckles were discovered in
cell nuclei. The main components of these complexes are SFPQ and NONO proteins and the …
cell nuclei. The main components of these complexes are SFPQ and NONO proteins and the …