The NLRP3 inflammasome in non-alcoholic fatty liver disease and steatohepatitis: Therapeutic targets and treatment

L Yu, W Hong, S Lu, Y Li, Y Guan, X Weng… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is among the most prevalent primary liver
diseases worldwide and can develop into various conditions, ranging from simple steatosis …

Emerging role of hepatic ketogenesis in fatty liver disease

RGR Mooli, SK Ramakrishnan - Frontiers in Physiology, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …

Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial

M Ezpeleta, K Gabel, S Cienfuegos, F Kalam, S Lin… - Cell metabolism, 2023 - cell.com
Innovative non-pharmacological lifestyle strategies to treat non-alcoholic fatty liver disease
(NAFLD) are critically needed. This study compared the effects of alternate day fasting (ADF) …

β-hydroxybutyrate as an Anti-Aging Metabolite

L Wang, P Chen, W Xiao - Nutrients, 2021 - mdpi.com
The ketone bodies, especially β-hydroxybutyrate (β-HB), derive from fatty acid oxidation and
alternatively serve as a fuel source for peripheral tissues including the brain, heart, and …

Mechanisms linking metabolic-associated fatty liver disease (MAFLD) to cardiovascular disease

OO Badmus, TD Hinds Jr, DE Stec - Current hypertension reports, 2023 - Springer
Abstract Purpose of Review Metabolic-associated fatty liver disease (MAFLD) is a condition
of fat accumulation in the liver that occurs in the majority of patients in combination with …

[HTML][HTML] Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis

S Asif, RY Kim, T Fatica, J Sim, X Zhao, Y Oh… - Molecular …, 2022 - Elsevier
Objective Aberrant ketogenesis is correlated with the degree of steatosis in non-alcoholic
fatty liver disease (NAFLD) patients, and an inborn error of ketogenesis (mitochondrial HMG …

The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function

Y Zhao, M Jia, W Chen, Z Liu - Free Radical Biology and Medicine, 2022 - Elsevier
Intermittent fasting (IF) has been studied for its effects on lifespan and the prevention or
delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria …

Bilirubin nanoparticles reduce diet-induced hepatic steatosis, improve fat utilization, and increase plasma β-hydroxybutyrate

TD Hinds Jr, JF Creeden, DM Gordon… - Frontiers in …, 2020 - frontiersin.org
The inverse relationship of plasma bilirubin levels with liver fat accumulation has prompted
the possibility of bilirubin as a therapeutic for non-alcoholic fatty liver disease. Here, we used …

Diet and exercise in NAFLD/NASH: beyond the obvious

G Semmler, C Datz, T Reiberger… - Liver International, 2021 - Wiley Online Library
Lifestyle represents the most relevant factor for non‐alcoholic fatty liver disease (NAFLD) as
the hepatic manifestation of the metabolic syndrome. Although a tremendous body of clinical …

[HTML][HTML] Myosteatosis: Diagnosis, pathophysiology and consequences in metabolic dysfunction-associated steatotic liver disease

G Henin, A Loumaye, IA Leclercq, N Lanthier - JHEP Reports, 2024 - Elsevier
Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with an
increased risk of multisystemic complications, including muscle changes such as sarcopenia …