Immunology of bile acids regulated receptors
Bile acids are steroids generated at the interface of host and intestinal microbiota. While
primary bile acids are generated in the liver from cholesterol metabolism, secondary bile …
primary bile acids are generated in the liver from cholesterol metabolism, secondary bile …
Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
JS Fleishman, S Kumar - Signal Transduction and Targeted Therapy, 2024 - nature.com
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …
Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders
The farnesoid-x-receptor (FXR) and the G protein bile acid activated receptor (GPBAR) 1 are
two bile acid activated receptors highly expressed in entero-hepatic, immune, adipose and …
two bile acid activated receptors highly expressed in entero-hepatic, immune, adipose and …
[HTML][HTML] Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are
chronic disorders characterized by dysregulated immune response and persistent …
chronic disorders characterized by dysregulated immune response and persistent …
[HTML][HTML] Microbial-derived bile acid reverses inflammation in IBD via GPBAR1 agonism and RORγt inverse agonism
M Biagioli, C Di Giorgio, C Massa, S Marchianò… - Biomedicine & …, 2024 - Elsevier
The interplay between the dysbiotic microbiota and bile acids is a critical determinant for
development of a dysregulated immune system in inflammatory bowel disease (IBD). Here …
development of a dysregulated immune system in inflammatory bowel disease (IBD). Here …
Nutraceutical formulation based on a synergic combination of melatonin and palmitoylethanolamide for the management of allergic events
The management of allergic events is a growing global health issue, especially in
industrialized countries. This disease is an immune-mediated process, regulated by the …
industrialized countries. This disease is an immune-mediated process, regulated by the …
[HTML][HTML] Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis
The leukemia inhibitory factor (LIF) is member of interleukin (IL)-6 family of cytokines
involved immune regulation, morphogenesis and oncogenesis. In cancer tissues, LIF binds …
involved immune regulation, morphogenesis and oncogenesis. In cancer tissues, LIF binds …
A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease
The interplay between the dysbiotic microbiota and bile acids is a critical determinant for
development of a dysregulated immune system in inflammatory bowel disease (IBD). Here …
development of a dysregulated immune system in inflammatory bowel disease (IBD). Here …
[PDF][PDF] Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in Oncogenesis
S Fiorucci - academia.edu
The leukemia inhibitory factor (LIF) is member of IL-6 family of cytokines involved immune
regulation, morphogenesis and oncogenesis. In cancer tissues, LIF binds a heterodimeric …
regulation, morphogenesis and oncogenesis. In cancer tissues, LIF binds a heterodimeric …