Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

The beneficial effects of oxytocin on infarct size and functional recovery of the ischemic
reperfused heart are well documented. The mechanisms for this cardioprotection are not …

Traditionally associated with female reproduction, oxytocin (OT) was revisited recently and
was revealed to have several new roles in the cardiovascular system. Functional OT …

Drug screening is a long and costly process confronted with low productivity and challenges
in using animals, which limit the discovery of new drugs. To improve drug screening efficacy …

While an increasing amount of evidence demonstrates the homeostatic functions of the
cardiac oxytocin (OT) system, less is known about the role of this hormone in the injured …

Objective—We examined the effect of delivery modality on the survival, localization, and
functional effects of exogenously administered embryonic stem cells (ESCs) or endothelial …

The understanding of nitric oxide (NO) signaling has grown substantially since the
identification of endothelial derived relaxing factor (EDRF). NO has emerged as a ubiquitous …

Diabetes mellitus (DM) is a chronic disease that results in a variety of systemic
complications. Recently, stem cell-based therapies have been proposed as potential …

Oxytocin (OT) emerges as a drug for the treatment of diabetes and obesity. The entire OT
system is synthesized in the rat and human heart. The direct myocardial infusion with OT into …

Oxytocin (OT) stimulates cardioprotection. Here we investigated heart-derived H9c2 cells in
simulated ischemia–reperfusion (I–R) experiments in order to examine the mechanism of OT …