Structure and function of telomeres
EH Blackburn - Nature, 1991 - nature.com
The DNA of telomeres—the terminal DNA-protein complexes of chromosomes—differs
notably from other DNA sequences in both structure and function. Recent work has …
notably from other DNA sequences in both structure and function. Recent work has …
Telomeres and their control
MJ McEachern, A Krauskopf… - Annual review of …, 2000 - annualreviews.org
▪ Abstract Telomeres are DNA and protein structures that form complexes protecting the
ends of chromosomes. Understanding of the mechanisms maintaining telomeres and …
ends of chromosomes. Understanding of the mechanisms maintaining telomeres and …
A human centromere antigen (CENP-B) interacts with a short specific sequence in alphoid DNA, a human centromeric satellite.
H Masumoto, H Masukata, Y Muro, N Nozaki… - The Journal of cell …, 1989 - rupress.org
We report the interaction between a human centromere antigen and an alphoid DNA, a
human centromeric satellite DNA, which consists of 170-bp repeating units. A cloned …
human centromeric satellite DNA, which consists of 170-bp repeating units. A cloned …
A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length
SH Askree, T Yehuda, S Smolikov… - Proceedings of the …, 2004 - National Acad Sciences
Telomeres are nucleoprotein structures present at the ends of eukaryotic chromosomes that
play a central role in guarding the integrity of the genome by protecting chromosome ends …
play a central role in guarding the integrity of the genome by protecting chromosome ends …
A mammalian factor that binds telomeric TTAGGG repeats in vitro
We have identified a DNA-binding activity with specificity for the TTAGGG repeat arrays
found at mammalian telomeres. This factor, called TTAGGG repeat factor (TRF), is present in …
found at mammalian telomeres. This factor, called TTAGGG repeat factor (TRF), is present in …
RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability
MN Conrad, JH Wright, AJ Wolf, VA Zakian - Cell, 1990 - cell.com
The protein encoded by the RAP7 gene of S. cerevisiae binds in vitro to a consensus
sequence occurring at a number of sites in the yeast genome, including the repeated …
sequence occurring at a number of sites in the yeast genome, including the repeated …
Human telomeres are attached to the nuclear matrix.
T de Lange - The EMBO journal, 1992 - embopress.org
This report shows that human telomeres are tightly associated with the nuclear matrix.
Telomere attachment is observed in several cell types and in all stages of interphase …
Telomere attachment is observed in several cell types and in all stages of interphase …
An overhanging 3′ terminus is a conserved feature of telomeres
ER Henderson, EH Blackburn - Molecular and cellular biology, 1989 - Taylor & Francis
The reactivity of single-stranded thymidines with osmium tetraoxide was used to
demonstrate the existence of a terminal overhang of the G-rich strand of telomeres from two …
demonstrate the existence of a terminal overhang of the G-rich strand of telomeres from two …
Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in …
AR Buchman, WJ Kimmerly, J Rine… - Molecular and cellular …, 1988 - Taylor & Francis
Two DNA-binding factors from Saccharomyces cerevisiae have been characterized, GRFI
(general regulatory factor I) and ABFI (ARS-binding factor I), that recognize specific …
(general regulatory factor I) and ABFI (ARS-binding factor I), that recognize specific …
Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length
The yeast protein RAP1, initially described as a transcriptional regulator, binds in vitro to
sequences found in a number of seemingly unrelated genomic loci. These include the …
sequences found in a number of seemingly unrelated genomic loci. These include the …