Purpose To investigate the ability of 18 F-FDG PET/CT to assess the response of patients
with metastatic melanoma to immunotherapy. Methods A comprehensive search of the …

Despite lengthening survival, death rates from metastatic colorectal cancer (CRC) remain
unacceptably high, with a bright spot being the demonstration of durable responses in …

Inducible T cell costimulator (ICOS, cluster of differentiation (CD278)) is an activating
costimulatory immune checkpoint expressed on activated T cells. Its ligand, ICOSL is …

Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell
death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells …

Objective We aimed to identify imaging biomarkers to assess predictive capacity of
radiomics nomogram regarding treatment response status (responder/non-responder) in …

Objectives A small subset of patients treated with immune checkpoint inhibitors manifest
atypical patterns of response, the so-called pseudoprogression (PP) and hyperprogression …

Cancer demands precise evaluation and accurate and timely assessment of response to
treatment. Imaging must be performed early during therapy to allow adjustments to the …

Immuno-oncology is an ever growing field that has seen important progress across the
spectrum of cancers. Responses can be deep and durable. However, as only a minority of …

The current standard of Response Evaluation Criteria in Solid Tumors (RECIST)–based
tumor response evaluation is limited in its ability to accurately monitor treatment response …

Immunotherapy approaches boosting spontaneous and durable antitumor immune
responses through immune checkpoint blockade are revolutionizing treatment and patient …