Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The population is aging at a rate never seen before in human history. As the number of
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …

In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …

Here, we present a physiologically relevant model of the human pulmonary alveoli. This
alveolar lung-on-a-chip platform is composed of a three-dimensional porous hydrogel made …

Aging promotes lung function decline and susceptibility to chronic lung diseases, which are
the third leading cause of death worldwide. Here, we use single cell transcriptomics and …

Tissue fibrosis is characterized by uncontrolled deposition and diminished clearance of
fibrous connective tissue proteins, ultimately leading to organ scarring. Yes-associated …

The airway epithelium serves as the interface between the host and external environment. In
many chronic lung diseases, the airway is the site of substantial remodeling after injury …

Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

The COVID‐19 pandemic rapidly spread around the world following the first reports in
Wuhan City, China in late 2019. The disease, caused by the novel SARS‐CoV‐2 virus, is …