Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

Brain homeostasis of transition metals is severely perturbed in Alzheimer's disease (AD),
with extracellular pooling of zinc and copper in amyloid, and intraneuronal accumulation of …

Elevation of both neuronal iron and nitric oxide (NO) in the substantia nigra are associated
with Parkinson's disease (PD) pathogenesis. We reported previously that the Alzheimer …

A set of common-acting iron-responsive 5′ untranslated region (5′ UTR) motifs can fold
into RNA stem loops that appear significant to the biology of cognitive declines of …

Many individuals with Parkinson's disease (PD) develop cognitive deficits, and a phenotypic
and molecular overlap between neurodegenerative diseases exists. We investigated the …

The exact physiological function of amyloid-β precursor protein (APP) in endothelial cells is
unknown. Endothelium-specific APP-deficient (eAPP−/−) mice were created to gain new …

The amyloid precursor protein (APP) has long been appreciated for its role in Alzheimer's
disease (AD) pathology. However, less is known about the physiologic function of APP …

Rapid phagocytosis of non-opsonized particles including apoptotic cells is an important
process that involves direct recognition of the target by multiple scavenger receptors …

Freezing of gait (FOG), a common, perplexing gait disorder observed in Parkinson's disease
(PD), is a leading cause of injurious falls and contributes significantly to social isolation …

A manifestation of Alzheimer's disease (AD) is the aggregation in the brain of amyloid β (Aβ)
peptides derived from the amyloid precursor protein (APP). APP has been linked to …