Unusually large cancer cells with abnormal nuclei have been documented in the cancer
literature since 1858. For more than 100 years, they have been generally disregarded as …

The skin is our largest organ and the outermost protective barrier. Its aging reflects both
intrinsic and extrinsic processes resulting from the constant insults it is exposed to. Aging in …

Poly (ADP) ribosylation inhibitors (PARPis) are toxic to cancer cells with homologous
recombination (HR) deficiency but not to HR-proficient cells in the tumor microenvironment …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcriptional regulator of antioxidant
and anti-inflammatory response in all cell types. It also activates the transcription of genes …

The progression of intervertebral disc degeneration (IDD) is multifactorial with the
senescence of nucleus pulposus (NP) cells and closely related to inflammation in NP cells …

Chronic inflammation affects many diseases and conditions, including aging. Interferons are
a part of the immune defense against viral infections. Paradoxically, various aging tissues …

Genomic instability is a key driving force for the development and progression of many
neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of …

Purpose This study aimed to evaluate if laryngopharyngeal reflux (LPR) plays a role as a
risk factor for vocal fold polyps (VFPs), and if pepsin is associated with higher oxidative DNA …

ABSTRACT A large number of studies have manifested long non-coding RNA (lncRNA) is
involved in the modulation of the development of periodontitis, but the specific mechanism …

Aim To investigate the role of GATA‐binding protein 4 (GATA4) in the inflammatory response
induced by DNA double‐strand breaks (DSBs) in human dental pulp cells (hDPCs) …