The early microbial colonization of human mucosal surfaces is essential for the development
of the host immune system. Already during pregnancy, the unborn child is prepared for the …

Introduction Preschool wheeze and school-aged asthma present a large healthcare burden.
Both conditions are now recognized to be heterogeneous, with similar symptom …

Introduction The COVID-19 pandemic has had devastating effects worldwide, but the
trajectory of the pandemic has been milder in Low-and-Middle-Income Countries (LMICs) …

Steroid-resistant asthma (SRA), resisting glucocorticoids such as dexamethasone (DEX), is
a bottleneck in the treatment of asthma. It is characterized by a predominantly neutrophilic …

Introduction Recent evidence has demonstrated that the microbiome is a driver of the
underlying pathophysiological mechanisms of respiratory disease. Studies have indicated …

Food allergens are the key triggers of allergic diarrhea, causing damage to the immune-rich
ileum. This weakens the mucosal barrier and tight junctions, increases intestinal …

Early infancy is a critical period for immune development. In addition to being the primary
food source during early infancy, human milk also provides multiple bioactive components …

Growth hormone-releasing hormone antagonists (GHRHAnt) have been associated with
antitumor and antioxidative activities. The present study investigates for the first time the …

Laboratory mice are instrumental for preclinical research but there are serious concerns that
the use of a clean standardized environment for specific-pathogen-free (SPF) mice results in …

Urbanization with reduced microbial exposure is associated with an increased burden of
asthma and atopic symptoms. Conversely, environmental exposure to endotoxins in …