The recognition of microbial or danger-associated molecular patterns by complement
proteins initiates a cascade of events that culminates in the activation of surface complement …

The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

Complement is viewed as a critical serum-operative component of innate immunity, with
processing of its key component, C3, into activation fragments C3a and C3b confined to the …

The complement system plays a crucial role in the innate defense against common
pathogens. Activation of complement leads to robust and efficient proteolytic cascades …

The diffuse-type gastric cancer (DGC) is a subtype of gastric cancer with the worst prognosis
and few treatment options. Here we present a dataset from 84 DGC patients, composed of a …

Complement is traditionally known to be a system of serum proteins that provide protection
against pathogens through direct cell lysis and the mobilization of innate and adaptive …

Reactivation of cytotoxic CD8+ T-cell responses has set a new direction for cancer
immunotherapy. Neutralizing antibodies targeting immune checkpoint programmed cell …

The complement system is an evolutionarily ancient key component of innate immunity
required for the detection and removal of invading pathogens. It was discovered more than …

The involvement of complement-activation products in promoting tumor growth has not yet
been recognized. Here we show that the generation of complement C5a in a tumor …

Photodynamic therapy (PDT) utilizes the destructive power of reactive oxygen species
generated via visible light irradiation of a photosensitive dye accumulated in the cancerous …