Pyroptosis is a lytic form of programmed cell death mediated by gasdermins (GSDMs) with
pore-forming activity in response to certain exogenous and endogenous stimuli. The …

Microneedles are a well-known transdermal or transdermal drug delivery system. Different
from intramuscular injection, intravenous injection, etc., the microneedle delivery system …

Metabolic dysfunction plays a key role in the development of diabetic nephropathy (DN).
However, the exact effects and mechanisms are still unclear. The pyrin domain‐containing …

Natural products have attracted extensive attention from researchers in medical fields due to
their abundant biological activities. Parthenolide (PTL) is a sesquiterpene lactone originally …

Dry eye disease (DED) affects a substantial worldwide population with increasing frequency.
Current single-targeting DED management is severely hindered by the existence of an …

Pyroptosis is a proinflammatory type of regulated cell death and has been involved in many
pathological processes. Inhibition of pyroptosis is thought to be a promising strategy for the …

Wear particles derived from implant surfaces are the important factors causing periprosthetic
osteolysis (PPO), which is the main reason for total joint revision. To date, the specific …

Ischemic stroke is a devastating disease in which mitochondrial damage or dysfunction
substantially contributes to brain injury. Mitochondrial uncoupling protein-2 (UCP2) is a …

Psoriasis is a common chronic autoinflammatory/autoimmune skin disease associated with
elevated pro-inflammatory cytokines. The pivotal role of interleukin (IL)-1β and nucleotide …

The fruits of Amomum villosum are often considered a medicinal and food homologous
material and have been found to have therapeutic effects in chronic enteritis, gastroenteritis …