Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

Gaucher disease (GD, ORPHA355) is a rare, autosomal recessive genetic disorder. It is
caused by a deficiency of the lysosomal enzyme, glucocerebrosidase, which leads to an …

B cell activation and differentiation yields plasma cells with high affinity antibodies to a given
antigen in a time-frame that allows for host protection. Although the end product is most …

Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …

The pivotal role of lysosomes in cellular processes is increasingly appreciated. An
understanding of the balanced interplay between the activity of acidic hydrolases, lysosomal …

The evolution and progression of multiple myeloma and its precursors over time is poorly
understood. Here, we investigate the landscape and timing of mutational processes shaping …

Adipocytes occupy 70% of the cellular volume within the bone marrow (BM) wherein
multiple myeloma (MM) originates and resides. However, the nature of the interaction …

Gaucher disease is caused by mutations in GBA1, which encodes the lysosomal enzyme
glucocerebrosidase (GCase). GBA1 mutations drive extensive accumulation of …

Gaucher disease (GD) is a rare, genetic lysosomal disorder leading to lipid accumulation
and dysfunction in multiple organs. Involvement of the skeleton is one of the most prevalent …

All cases of multiple myeloma (MM) are preceded by precursor states termed monoclonal
gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). Genetic …