Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis

Q Ye, B Zou, YH Yeo, J Li, DQ Huang, Y Wu… - The lancet …, 2020 - thelancet.com
Background Although non-alcoholic fatty liver disease (NAFLD) is commonly associated
with obesity, it is increasingly being identified in non-obese individuals. We aimed to …

An observational data meta-analysis on the differences in prevalence and risk factors between MAFLD vs NAFLD

GEH Lim, A Tang, CH Ng, YH Chin, WH Lim… - Clinical …, 2023 - Elsevier
Background & Aims The shift to redefine nonalcoholic fatty liver disease (NAFLD) as
metabolic associated fatty liver disease (MAFLD) can profoundly affect patient care, health …

Liver diseases in the Asia-Pacific region: a lancet gastroenterology & hepatology commission

SK Sarin, M Kumar, M Eslam, J George… - The lancet …, 2020 - thelancet.com
Summary The Asia-Pacific region is home to more than half of the global population and
accounted for 62· 6% of global deaths due to liver diseases in 2015. 54· 3% of global deaths …

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Z Younossi, QM Anstee, M Marietti, T Hardy… - Nature reviews …, 2018 - nature.com
NAFLD is one of the most important causes of liver disease worldwide and will probably
emerge as the leading cause of end-stage liver disease in the coming decades, with the …

Lean NAFLD: a distinct entity shaped by differential metabolic adaptation

F Chen, S Esmaili, GB Rogers, E Bugianesi, S Petta… - Hepatology, 2020 - journals.lww.com
Conclusions This study demonstrates that E. multilocularis can induce T‐cell exhaustion
through inhibitory receptor TIGIT, and that blocking this checkpoint may reverse the …

[HTML][HTML] Metabolic-associated fatty liver disease (MAFLD): a multi-systemic disease beyond the liver

E Kaya, Y Yilmaz - Journal of clinical and translational hepatology, 2022 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a multisystemic clinical condition that presents
with a wide spectrum of extrahepatic manifestations, such as obesity, type 2 diabetes …

[HTML][HTML] NASH in lean individuals

R Younes, E Bugianesi - Seminars in liver disease, 2019 - thieme-connect.com
Nonalcoholic fatty liver disease (NAFLD) is generally associated with obesity and the related
comorbidities but it can also develop in subjects with a body mass index (BMI) within the …

Comparative burden of metabolic dysfunction in lean NAFLD vs non-lean NAFLD-a systematic review and meta-analysis

A Tang, CH Ng, PH Phang, KE Chan, YH Chin… - Clinical …, 2023 - Elsevier
Background & Aims Nonalcoholic fatty liver disease (NAFLD) is traditionally associated with
obesity. However, there is a subtype of NAFLD, namely NAFLD in lean, that occurs without …

Nonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management

T Marjot, A Moolla, JF Cobbold, L Hodson… - Endocrine …, 2020 - academic.oup.com
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disease, extending from simple
steatosis to inflammation and fibrosis with a significant risk for the development of cirrhosis. It …

[PDF][PDF] Histological severity and clinical outcomes of nonalcoholic fatty liver disease in nonobese patients

JCF Leung, TCW Loong, JL Wei, GLH Wong… - …, 2017 - Wiley Online Library
Although nonalcoholic fatty liver disease (NAFLD) is closely linked to obesity, around 10%‐
20% of nonobese Americans and Asians still develop NAFLD. Data on this special group …