Antiviral prophylaxis for cytomegalovirus infection in allogeneic hematopoietic cell transplantation

K Chen, MP Cheng, SP Hammond, H Einsele… - Blood …, 2018 - ashpublications.org
Patients treated with allogeneic hematopoietic cell transplantation (HCT) are at risk of
cytomegalovirus (CMV) reactivation and disease, which results in increased morbidity and …

Viral infections in HSCT: detection, monitoring, clinical management, and immunologic implications

C Annaloro, F Serpenti, G Saporiti, G Galassi… - Frontiers in …, 2021 - frontiersin.org
In spite of an increasing array of investigations, the relationships between viral infections
and allogeneic hematopoietic stem cell transplantation (HSCT) are still controversial, and …

[HTML][HTML] American Society for Transplantation and Cellular Therapy series:# 3—prevention of cytomegalovirus infection and disease after hematopoietic cell …

M Hakki, SL Aitken, L Danziger-Isakov… - … and Cellular Therapy, 2021 - Elsevier
Abstract The Practice Guidelines Committee of the American Society for Transplantation and
Cellular Therapy partnered with its Transplant Infectious Disease Special Interest Group to …

Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT

A Papadopoulou, U Gerdemann, UL Katari… - Science translational …, 2014 - science.org
It remains difficult to treat the multiplicity of distinct viral infections that afflict
immunocompromised patients. Adoptive transfer of virus-specific T cells (VSTs) can be safe …

Third-party cytomegalovirus-specific T cells improved survival in refractory cytomegalovirus viremia after hematopoietic transplant

SE Prockop, A Hasan, E Doubrovina… - The Journal of …, 2023 - Am Soc Clin Investig
Background Refractory CMV viremia and disease are associated with significant morbidity
and mortality in recipients of hematopoietic stem cell transplant (HCT). Methods In phase I/II …

Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation

E Blyth, L Clancy, R Simms, CKK Ma… - Blood, The Journal …, 2013 - ashpublications.org
We investigated the use of adoptively transferred donor-derived cytomegalovirus (CMV)
specific cytotoxic T lymphocytes (CTL) as immune reconstitution postallogeneic transplant in …

Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem …

AM Leen, A Christin, GD Myers, H Liu… - Blood, The Journal …, 2009 - ashpublications.org
Viral infection or reactivation remains a major cause of morbidity and mortality after
allogeneic stem cell transplantation. We now show that infusions of single cytotoxic T …

Directly selected cytomegalovirus-reactive donor T cells confer rapid and safe systemic reconstitution of virus-specific immunity following stem cell transplantation

KS Peggs, K Thomson, E Samuel, G Dyer… - Clinical infectious …, 2011 - academic.oup.com
Background. Adoptive transfer of virus-specific T cells may accelerate reconstitution of
antigen-specific immunity and limit the morbidity and mortality of viral infections following …

Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects

JJ Melenhorst, AM Leen, CM Bollard… - Blood, The Journal …, 2010 - ashpublications.org
Adoptive transfer of viral antigen-specific memory T cells can reconstitute antiviral immunity,
but in a recent report a majority of virus-specific cytotoxic T-lymphocyte (CTL) lines showed …

Pre‐transplant cytomegalovirus (CMV) serostatus remains the most important determinant of CMV reactivation after allogeneic hematopoietic stem cell transplantation …

B George, N Pati, N Gilroy… - Transplant infectious …, 2010 - Wiley Online Library
B. George, N. Pati, N. Gilroy, M. Ratnamohan, G. Huang, I. Kerridge, M. Hertzberg, D.
Gottlieb, K. Bradstock. Pre‐transplant cytomegalovirus (CMV) serostatus remains the most …