Background: Interferon-γ–release assays (IGRAs) are alternatives to the tuberculin skin test
(TST). A recent meta-analysis showed that IGRAs have high specificity, even among …

Tuberculosis is recognized as the world's leading bacterial cause of death. Yet 95% of
infection is believed to exist in an asymptomatic 'latent'form that is defined not by the …

Background: Until recently, the tuberculin skin test was the only test for detecting latent
tuberculosis (TB) infection, but 2 ex vivo interferon-γ release assays (IGRAs) are now …

Background. Diagnosis of childhood tuberculosis (TB) is challenging. The widely used
tuberculin skin test (TST) may produce-positive results because of cross-reactivity with …

Distinct IFN-γ and IL-2 profiles of Ag-specific CD4+ T cells have recently been associated
with different clinical disease states and Ag loads in viral infections. We assessed the …

Background Although tuberculosis (TB) is a minor problem in Denmark, severe and
complicated cases occur in HIV positive. Since the new M. tuberculosis specific test for latent …

Children account for a major proportion of the global tuberculosis disease burden,
especially in endemic areas. However, the accurate diagnosis of childhood tuberculosis …

Over three previous editions, Clinical Tuberculosis has established itself as an
indispensable guide to all aspects of tuberculosis diagnosis and treatment. This fully revised …

Rationale: The kinetics of Mycobacterium tuberculosis–specific Th1-type T-cell responses
after M. tuberculosis infection are likely to be important in determining clinical outcome …

IGRAs may still be useful in high-burden settings in specific subgroups at high risk of
progression, including young children, HIV-infected individuals and healthcare workers, but …