Early intervention for children with intellectual disabilities: An update

MJ Guralnick - Journal of Applied Research in Intellectual …, 2017 - Wiley Online Library
This article provides an update on advances in both developmental and intervention science
that have occurred in the field of early intervention for children with developmental delays in …

Modeling fragile X syndrome in the Fmr1 knockout mouse

TM Kazdoba, PT Leach, JL Silverman… - Intractable & rare …, 2014 - jstage.jst.go.jp
Summary Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability
and one of the leading genetic causes for autism spectrum disorder. Clinical symptoms of …

Autistic behavior in children with fragile X syndrome: prevalence, stability, and the impact of FMRP

DD Hatton, J Sideris, M Skinner… - American journal of …, 2006 - Wiley Online Library
We examined autistic behavior in a cross‐sectional sample of 179 children with fragile X
syndrome (FXS) and a longitudinal subset of 116 children using the Childhood Autism …

Developmental studies in fragile X syndrome

KA Razak, KC Dominick, CA Erickson - Journal of neurodevelopmental …, 2020 - Springer
Fragile X syndrome (FXS) is the most common single gene cause of autism and intellectual
disabilities. Humans with FXS exhibit increased anxiety, sensory hypersensitivity, seizures …

Ras and Rap signaling in synaptic plasticity and mental disorders

RL Stornetta, JJ Zhu - The Neuroscientist, 2011 - journals.sagepub.com
The Ras family GTPases (Ras, Rap1, and Rap2) and their downstream mitogen-activated
protein kinases (ERK, JNK, and p38MAPK) and PI3K signaling cascades control various …

The fragile X continuum: new advances and perspectives

K Cornish, J Turk, R Hagerman - Journal of Intellectual …, 2008 - Wiley Online Library
Fragile X syndrome is the world's most common hereditary cause of intellectual disability in
men and to a lesser extent in women. The disorder is caused by the silencing of a single …

ASD comorbidity in fragile X syndrome: Symptom profile and predictors of symptom severity in adolescent and young adult males

L Abbeduto, AJ Thurman, A McDuffie, J Klusek… - Journal of Autism and …, 2019 - Springer
Many males with FXS meet criteria for ASD. This study was designed to (1) describe ASD
symptoms in adolescent and young adult males with FXS (n= 44) and (2) evaluate the …

Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome

H Hu, Y Qin, G Bochorishvili, Y Zhu… - Journal of …, 2008 - Soc Neuroscience
Fragile X syndrome, caused by the loss of FMR1 gene function and loss of fragile X mental
retardation protein (FMRP), is the most commonly inherited form of mental retardation. The …

Symptoms of autism in males with fragile X syndrome: A comparison to nonsyndromic ASD using current ADI-R scores

A McDuffie, AJ Thurman, RJ Hagerman… - Journal of autism and …, 2015 - Springer
Symptoms of autism are frequent in males with fragile X syndrome (FXS), but it is not clear
whether symptom profiles differ from those of nonsyndromic ASD. Using individual item …

Public health literature review of fragile X syndrome

M Raspa, AC Wheeler, C Riley - Pediatrics, 2017 - publications.aap.org
OBJECTIVES: The purpose of this systematic literature review is to describe what is known
about fragile X syndrome (FXS) and to identify research gaps. The results can be used to …