We are currently witnessing transformative change for people with cystic fibrosis with the
introduction of small molecule, mutation-specific drugs capable of restoring function of the …

Pulmonary MRI can now provide high‐resolution images that are sensitive to early disease
and specific to inflammation in cystic fibrosis (CF) lung disease. With specificity and function …

Background Lumacaftor and ivacaftor combination treatment showed efficacy in patients
aged 12 years or older with cystic fibrosis homozygous for F508del-cystic fibrosis …

Pulmonary MRI provides structural and quantitative functional images of the lungs without
ionizing radiation, but it has had limited clinical use due to low signal intensity from the lung …

Hyperpolarised gas lung MRI using xenon-129 can provide detailed 3D images of the
ventilated lung airspaces, and can be applied to quantify lung microstructure and detailed …

Bronchiolitis obliterans (BO) is a rare, chronic form of obstructive lung disease, often initiated
with injury of the bronchiolar epithelium followed by an inflammatory response and …

The use of pulmonary MRI in a clinical setting has historically been limited. Whilst CT
remains the gold-standard for structural lung imaging in many clinical indications, technical …

Objective Imaging represents an important noninvasive means to assess cystic fibrosis (CF)
lung disease, which remains the main cause of morbidity and mortality in CF patients. While …

Background A recent single-centre study demonstrated that MRI is sensitive to detect early
abnormalities in the lung and response to therapy in infants and preschool children with …

Background Free‐breathing 1H ventilation MRI shows promise but only single‐center
validation has yet been performed against methods which directly image lung ventilation in …