Portal hypertension and related complications: diagnosis and management

DA Simonetto, M Liu, PS Kamath - Mayo Clinic Proceedings, 2019 - Elsevier
Portal hypertension is a major complication of cirrhosis, and its consequences, including
ascites, esophageal varices, hepatic encephalopathy, and hepatorenal syndrome, lead to …

[HTML][HTML] Beta-blockers in cirrhosis: Evidence-based indications and limitations

SG Rodrigues, YP Mendoza, J Bosch - JHEP reports, 2020 - Elsevier
Non-selective beta-blockers (NSBBs) are the mainstay of treatment for portal hypertension in
the setting of liver cirrhosis. Randomised controlled trials demonstrated their efficacy in …

[PDF][PDF] Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of …

G Garcia‐Tsao, JG Abraldes, A Berzigotti… - Hepatology, 2017 - Wiley Online Library
This guidance provides a data-supported approach to risk stratification, diagnosis, and
management of patients with cirrhosis and portal hypertension (PH). A guidance document …

[PDF][PDF] Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis

G Garcia‐Tsao, AJ Sanyal, ND Grace, W Carey… - …, 2007 - Wiley Online Library
These recommendations provide a data-supported approach to the management of patients
with varices and variceal hemorrhage. They are based on the following:(1) formal review …

The clinical use of HVPG measurements in chronic liver disease

J Bosch, JG Abraldes, A Berzigotti… - Nature reviews …, 2009 - nature.com
Portal hypertension is a severe, almost unavoidable complication of chronic liver diseases
and is responsible for the main clinical consequences of cirrhosis. Measurement of the …

Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis

C Ripoll, R Groszmann, G Garcia–Tsao, N Grace… - Gastroenterology, 2007 - Elsevier
Background & Aims: Our aim was to identify predictors of clinical decompensation (defined
as the development of ascites, variceal hemorrhage [VH], or hepatic encephalopathy [HE]) in …

[HTML][HTML] Evolution in the understanding of the pathophysiological basis of portal hypertension: how changes in paradigm are leading to successful new treatments

J Bosch, RJ Groszmann, VH Shah - Journal of hepatology, 2015 - Elsevier
Among the common complication of cirrhosis portal hypertension witnessed a major
improvement of prognosis during the past decades. Principally due to the introduction of …

Clinical course of alcoholic liver cirrhosis: a Danish population‐based cohort study

P Jepsen, P Ott, PK Andersen, HT Sørensen… - …, 2010 - Wiley Online Library
The clinical course of alcoholic cirrhosis, a condition with a high mortality, has not been well
described. We examined prevalence, risk, chronology, and mortality associated with three …

Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis

T Reiberger, A Ferlitsch, BA Payer, M Mandorfer… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: We evaluated the gastrointestinal permeability and bacterial
translocation in cirrhotic patients with portal hypertension (PHT) prior to and after non …

Bacterial infections, sepsis, and multiorgan failure in cirrhosis

P Tandon, G Garcia-Tsao - Seminars in liver disease, 2008 - thieme-connect.com
Bacterial infections are an important complication of cirrhosis, particularly in hospitalized
patients. In this article we review the prevalence, risk factors, and pathogenesis of bacterial …