Interactions among leukocytes and leukocytes with immune-associated auxiliary cells
represent an essential feature of the immune response that requires the involvement of cell …

From the thymus to the peripheral lymph nodes, integrin-mediated interactions with neighbor
cells and the extracellular matrix tune T cell behavior by organizing cytoskeletal remodeling …

The heart is an autoimmune-prone organ. It is crucial for the heart to keep injury-induced
autoimmunity in check to avoid autoimmune-mediated inflammatory disease. However, little …

Regulatory T cells (Tregs) control adaptive immunity and restrain type 2 inflammation in
allergic disease. Interleukin-33 promotes the expansion of tissue-resident Tregs and group 2 …

Sophoridine is a natural quinolizidine alkaloid and a bioactive ingredient that can be
isolated and identified from certain herbs, including Sophora flavescens Alt, Sophora …

Regulatory T cells (Tregs) are a subset of immune cells that suppress the immune response.
Treg therapy for inflammatory diseases is being tested in the clinic, with moderate success …

Thymic dendritic cells (tDCs) play an important role in central tolerance by eliminating self-
reactive thymocytes or differentiating them to regulatory T (Treg) cells. However, the …

Lymphocyte development is a complex and coordinated pathway originating from
pluripotent stem cells during embryogenesis and continuing even as matured lymphocytes …

Abstract Background Fingolimod, a sphingosine-1-phosphate receptor modulator with well-
described immunomodulatory properties involving peripheral immune cell trafficking, was …

Regulatory T cells (Tregs) are essential for maintaining immune tolerance in both lymphoid
and non-lymphoid tissues. We discovered that layilin, a C-type lectin receptor, is …