Aging of the immune system in humans and animals is characterized by a decline in both
adaptive and innate immune responses. Paradoxically, aging is also associated with a state …

Systemic lupus erythematosus (SLE) is an autoimmune disease with manifestations derived
from the involvement of multiple organs including the kidneys, joints, nervous system and …

Infection caused by SARS-CoV-2 can result in severe respiratory complications and death.
Patients with a compromised immune system are expected to be more susceptible to a …

The Nrf2-Keap1-ARE pathway is the principal regulator of antioxidant and phase II
detoxification genes. Its activation increases the expression of antioxidant and cytoprotective …

Systemic lupus erythematosus is a complex autoimmune disease caused by genetic and
epigenetic alterations. DNA methylation abnormalities play an important role in systemic …

Objective To identify microRNA genes with abnormal expression in the CD4+ T cells of
patients with systemic lupus erythematosus (SLE) and to determine the role of microRNA …

One of the major disappointments in human autoimmunity has been the relative failure on
genome-wide association studies to provide “smoking genetic guns” that would explain the …

T cells contribute to the initiation and perpetuation of autoimmunity in systemic lupus
erythematosus (SLE), and seem to be directly involved in the development of related organ …

Self tolerance loss is fundamental to autoimmunity. While understanding of immune
regulation is expanding rapidly, the mechanisms causing loss of tolerance in most …

Systemic lupus erythematosus (SLE) is characterized by the production of a wide array of
autoantibodies. Thus, the condition was traditionally classified as a “B‐cell disease” …