Glycosaminoglycans (GAGs) are a family of linear and negatively charged polysaccharides
that exist ubiquitously on the human cell surface as well as in the extracellular matrix. GAGs …

Surgical repair of severe peripheral nerve injuries represents not only a pressing medical
need, but also a great clinical challenge. Autologous nerve grafting remains a golden …

Heparin, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has
numerous important biological activities, associated with its interaction with diverse proteins …

Cells are mechanically coupled to their extracellular environments, which play critical roles
in both communicating the state of the mechanical environment to the cell as well as in …

Without new blood vessels, neoplasms cannot expand beyond a few millimeters, the point at
which the diffusion of nutrients and the disposal of waste products become rate-limiting …

Peripheral nerves possess the capacity of self‐regeneration after traumatic injury.
Transected peripheral nerves can be bridged by direct surgical coaptation of the two nerve …

Little is known about the migration of mesenchymal stem cells (MSCs). Some therapeutic
approaches had demonstrated that MSCs were able to regenerate injured tissues when …

Pluripotent or multipotent stem cells isolated from human embryos or adult central nervous
system (CNS) may provide new neurons to ameliorate neural disorders. A major obstacle …

The signaling activities of multiple developmental ligands require sulfated heparan sulfate
(HS) proteoglycans as coreceptors. QSulf1 and its mammalian orthologs are cell surface HS …

In vitro endothelial cell organization into capillaries is a long standing challenge of tissue
engineering. We recently showed the utility of low level interstitial flow in guiding the …