Lipid droplets (LDs) are multi-functional cellular organelles that store energy, and regulate
many aspects of cell physiology. However, our understanding of the biogenesis of LDs …

Amphipathic helices (AHs), a secondary feature found in many proteins, are defined by their
structure and by the segregation of hydrophobic and polar residues between two faces of …

How proteins control the biogenesis of cellular lipid droplets (LDs) is poorly understood.
Using Drosophila and human cells, we show here that seipin, an ER protein implicated in …

Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …

The biogenesis of lipid droplets (LDs) and the development of adipocytes are two key
aspects of mammalian fat storage. SEIPIN, an integral membrane protein of the endoplasmic …

Construction of living artificial cells from genes and molecules can expand our
understanding of life system and establish a new aspect of bioengineering. However, growth …

Mitochondria are dynamic organelles regulated by fission and fusion processes. The fusion
of membranes requires elaborative coordination of proteins and lipids and is particularly …

Lipid droplets (LDs) are storage organelles consisting of a neutral lipid core surrounded by a
phospholipid monolayer and a set of LD-specific proteins. Most LD components are …

Membrane surface charge is critical for the transient, yet specific recruitment of proteins with
polybasic regions to certain organelles. In eukaryotes, the plasma membrane (PM) is the …

Perilipins (PLINs) play a key role in energy storage by orchestrating the activity of lipases on
the surface of lipid droplets. Failure of this activity results in severe metabolic disease in …