Vitamin D has well-documented effects on calcium homeostasis and bone metabolism but
recent studies suggest a much broader role for this secosteroid in human health. Key …

A high prevalence of vitamin D (calcidiol) serum deficiency has been described in several
autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis (AR), and …

Vitamin D plays an important role in maintaining a healthy mineralized skeleton. It is also
considered an immunomodulatory agent that regulates innate and adaptive immune …

Evidence supporting the extra-skeletal role of vitamin D in modulating immune responses is
centred on the effects of its final metabolite, 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3, also …

Simple Summary The pathogenesis of autoimmune diseases etiology is still mostly unclear
and probably arises from an interplay between common/rare genetic variants and …

Background The association between the polymorphisms in the vitamin D receptor (VDR)
gene and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies …

Several studies have noted that vitamin D receptor (VDR) gene polymorphisms are involved
in the susceptibility to Coronary artery disease (CAD). Nonetheless, the results have been …

Vitamin D is an important hormone involved in various physiologic processes, and its activity
is linked to binding with vitamin D receptor (VDR). Genetic polymorphisms in the VDR gene …

Background Peptidyl arginine deiminase 4 (PADI4) has been implicated in Rheumatoid
arthritis (RA) pathogenesis. Here we aimed to evaluate the association of PADI4 gene …

Background: Previous studies have shown that several microRNAs (miRNAs) are
dysregulated in the whole blood as well as diverse cells and tissues from rheumatoid …