Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …

The process for drug discovery and development is challenging, time consuming and
expensive. Computer-aided drug discovery (CADD) tools can act as a virtual shortcut …

Over the past decade we have witnessed the increasing sophistication of machine learning
algorithms applied in daily use from internet searches, voice recognition, social network …

In this review we will discuss recent advances in computational prediction of solubility in
water-based solvents. Our focus is set on recent advances in predictions of biorelevant …

The physicochemical properties of some contemporary drug candidates are moving towards
higher molecular weight, and coincidentally also higher lipophilicity in the quest for …

Sažetak This commentary addresses data quality in equilibrium solubility measurement in
aqueous solution. Broadly discussed is the “gold standard” shake-flask (SF) method used to …

Abstract Methicillin-Resistant Staphylococcus aureus (MRSA), a pathogenic bacterium that
causes life-threatening outbreaks such as community-onset and nosocomial infections as …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

The oral drug bioavailability (BA) problems have remained inevitable over the years,
impairing drug efficacy and indirectly leading to eventual human morbidity and mortality …

Dissolution testing with biorelevant media has become widespread in the pharmaceutical
industry as a means of better understanding how drugs and formulations behave in the …