Molecular mechanisms of melatonin-mediated cell protection and signaling in health and disease

DM Kopustinskiene, J Bernatoniene - Pharmaceutics, 2021 - mdpi.com
Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting
beneficial action in many pathological conditions. Melatonin protects from oxidative stress in …

Plasmodium Egress Across the Parasite Life Cycle

JD Dvorin, DE Goldberg - Annual review of microbiology, 2022 - annualreviews.org
Human malaria, caused by infection with Plasmodium parasites, remains one of the most
important global public health problems, with the World Health Organization reporting more …

[图书][B] Toxoplasma gondii: the model apicomplexan-perspectives and methods

LM Weiss - 2013 - books.google.com
This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years,
including new information on the genomics, epigenomics and proteomics of T. gondii as well …

Temporal and thermal profiling of the Toxoplasma proteome implicates parasite Protein Phosphatase 1 in the regulation of Ca2+-responsive pathways

AL Herneisen, ZH Li, AW Chan, SNJ Moreno… - Elife, 2022 - elifesciences.org
Apicomplexan parasites cause persistent mortality and morbidity worldwide through
diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca 2+ signaling pathways …

Calcium signalling in malaria parasites

M Brochet, O Billker - Molecular microbiology, 2016 - Wiley Online Library
Ca2+ is a ubiquitous intracellular messenger in malaria parasites with important functions in
asexual blood stages responsible for malaria symptoms, the preceding liver‐stage infection …

Functional Characterization and Target Validation of Alternative Complex I of Plasmodium falciparum Mitochondria

GA Biagini, P Viriyavejakul, PM O'neill… - Antimicrobial agents …, 2006 - Am Soc Microbiol
This study reports on the first characterization of the alternative NADH: dehydrogenase (also
known as alternative complex I or type II NADH: dehydrogenase) of the human malaria …

Melatonin and IP3-induced Ca2+ release from intracellular stores in the malaria parasite Plasmodium falciparum within infected red blood cells

E Alves, PJ Bartlett, CRS Garcia, AP Thomas - Journal of Biological …, 2011 - ASBMB
IP 3-dependent Ca 2+ signaling controls a myriad of cellular processes in higher eukaryotes
and similar signaling pathways are evolutionarily conserved in Plasmodium, the intracellular …

Calcium regulation and signaling in apicomplexan parasites

K Nagamune, SN Moreno, EN Chini… - Molecular Mechanisms of …, 2008 - Springer
Apicomplexan parasites rely on calcium-mediated signaling for a variety of vital functions
including protein secretion, motility, cell invasion, and differentiation. These functions are …

[PDF][PDF] The malaria digestive vacuole

J Wunderlich, P Rohrbach, JP Dalton - Front. Biosci, 2012 - researchgate.net
Introduction 3. Structure and formation of the DV 4. Hemoglobin digestion 5. Ion
homeostasis 5.1. pH homeostasis 5.2. Calcium homeostasis 6. Transporters in the DV …

Synthetic indole and melatonin derivatives exhibit antimalarial activity on the cell cycle of the human malaria parasite Plasmodium falciparum

DC Schuck, AK Jordão, M Nakabashi… - European Journal of …, 2014 - Elsevier
Discovering the mechanisms by which cell signaling controls the cell cycle of the human
malaria parasite Plasmodium falciparum is fundamental to designing more effective …