The therapeutic challenge of late antibody‐mediated kidney allograft rejection

GA Böhmig, F Eskandary, K Doberer… - Transplant …, 2019 - Wiley Online Library
Late antibody‐mediated rejection (ABMR) is a cardinal cause of kidney allograft failure,
manifesting as a continuous and, in contrast with early rejection, often clinically silent …

Immunosuppression in kidney transplantation: state of the art and current protocols

AC Bauer, RF Franco, RC Manfro - Current Pharmaceutical …, 2020 - ingentaconnect.com
Currently, kidney transplantation is the best treatment option for kidney failure for a majority
of eligible patients. It is associated with a better quality of life and reduced mortality as …

Subclinical antibody-mediated rejection after kidney transplantation: treatment outcomes

S Parajuli, E Joachim, S Alagusundaramoorthy… - …, 2019 - journals.lww.com
Background. Antibody-mediated rejection (AMR) is a leading cause of morbidity and
mortality after kidney transplantation. Early diagnosis and treatment of subclinical AMR …

Antibody-mediated rejection: prevention, monitoring and treatment dilemmas

S Rodriguez-Ramirez, A Al Jurdi… - Current opinion in …, 2022 - journals.lww.com
The ability to personalize management for a given kidney transplant recipient and identify
treatments that will improve their long-term outcome remains a critical unmet need. Earlier …

[HTML][HTML] Histopathological characteristics and causes of kidney graft failure in the current era of immunosuppression

S Parajuli, F Aziz, N Garg, SE Panzer… - World Journal of …, 2019 - ncbi.nlm.nih.gov
BACKGROUND The histopathological findings on the failing kidney allograft in the modern
era is not well studied. In this study, we present our experience working with kidney …

Clinical significance of microvascular inflammation in the absence of anti-HLA DSA in kidney transplantation

S Parajuli, RR Redfield, N Garg, F Aziz… - …, 2019 - journals.lww.com
Background. Limited information exists about outcomes of HLA donor-specific antibody
(DSA) negative (DSA−) microvascular inflammation (MVI). Methods. We report our …

[HTML][HTML] Donor-specific antibodies in the absence of rejection are not a risk factor for allograft failure

S Parajuli, E Joachim, S Alagusundaramoorthy… - Kidney International …, 2019 - Elsevier
Introduction Donor-specific antibodies (DSAs) are considered an important risk factor for
graft injury and failure. However, there is limited information on long-term outcomes for …

Bruton's tyrosine kinase ablation inhibits B cell responses and antibody production for the prevention of chronic rejection in cardiac transplantation

F Han, X Shi, T Liao, W Zhang, M Ma, Q Leng… - Clinical …, 2024 - Elsevier
Chronic rejection is the primary cause of late allograft failure, however, the current
treatments for chronic rejection have not yielded desirable therapeutic effects. B cell …

Photopheresis abates the anti-HLA antibody titer and renal failure progression in chronic antibody-mediated rejection

M Gregorini, C Del Fante, EF Pattonieri, MA Avanzini… - Biology, 2021 - mdpi.com
Simple Summary The most common cause of late allograft failure is chronic active antibody-
mediated rejection (ABMR), but no effective therapy is available. Different …

Therapeutic apheresis in renal transplantation: An update

M Christina, F Vassilis, M Smaragdi - Transfusion and Apheresis Science, 2023 - Elsevier
Therapeutic apheresis (TA) plays a significant role in various aspects of renal
transplantation. It has been a necessary preconditioning component in ABO incompatible …