The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular
processes, including the regulation of transcription, apoptosis and the DNA damage …

The past 20 years have seen dramatic changes in the delivery of radiation therapy, but the
impact of radiobiology on the clinic has been far less substantial. A major consideration in …

Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR
genes are established cancer susceptibility genes with clinically actionable pathogenic …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a critical DNA repair enzyme in the base
excision repair pathway. Inhibitors of this enzyme comprise a new type of anticancer drug …

Poly (ADP-ribose) polymerases (PARP) are proteins responsible for DNA damage detection
and signal transduction. PARP inhibitors (PARPi) are able to interact with the binding site for …

Endometrial cancer is the most prevalent gynecologic cancer in the United States. Over the
last 10 years, death rates from endometrial cancer have been rising about 1.4% per year …

Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular
responses to DNA damage. This feature of malignant cells opens new avenues for tumor …

DNA damage response (DDR) deficiencies result in genome instability, which is one of the
hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various …

Purpose: PARP inhibitors (PARPi) are primarily effective against BRCA1/2-mutated breast
and ovarian cancers, but resistance due to reversion of mutated BRCA1/2 and other …

Breast cancer is the most common malignancy in women all over the world. Genetic
background of women contributes to her risk of having breast cancer. Certain inherited DNA …