Determination of pKa Values for Some Benzimidazole and Imidazole Group Drugs Using the Reversed-Phase Liquid Chromatography Method

K Poturcu, EC Demiralay - Journal of Chemical & Engineering …, 2020 - ACS Publications
The benzimidazole and imidazole rings are the most important heterocyclic structures that
show a promising application in the pharmaceutical industry. Many potent marketed drugs …

Chromatographic and UV–visible spectrophotometric pKa determination of some purine antimetabolites

YD Daldal, EÇ Demiralay - Journal of Molecular Liquids, 2020 - Elsevier
In this study, the chromatographic and spectrophotometric behaviors of polar 6-thioguanine
(6-TGN) and 6-mercaptopurine (6-MCP) in acetonitrile (ACN)-water binary mixtures were …

Determination of some physicochemical properties of mebendazole with RPLC method

K Poturcu, E Çubuk Demiralay - Journal of Chemical & …, 2019 - ACS Publications
In this study, the retention behavior of benzimidazole anthelmintic drug mebendazole (MBZ)
was investigated with a liquid chromatographic method. Influence of acetonitrile (ACN) …

[PDF][PDF] Thermodynamic protonation constant values of meclizine and buclizine in acetonitrile-water binary mixtures

ID Nane, EC Demiralay - Journal of Research in Pharmacy, 2021 - researchgate.net
In the study, the retention times (tR) values for meclizine (MCZ) and buclizine (BCZ)
structurally related benzhydrylpiperazine were determined to modeling the dependence of …

Optimization of RPLC conditions for quantitative analysis of Atorvastatin and Rosuvastatin in pharmaceutical dosage form

Z Üstün, A Talay, EÇ Demiralay - … of Arts and Science Journal of …, 2016 - dergipark.org.tr
In this study, a simple reverse phase liquid chromatographic (RPLC) method has been
developed and subsequently validated for simultaneous determination of atorvastatin (ATV) …

Pravastatinin Su ve Su-Asetonitril İkili Karışımlarında İyonlaşma Sabiti Değerinin RPLC Metoduyla Belirlenmesi

ME Tanrıkulu, İ Konçe, EÇ Demiralay - … Demirel Üniversitesi Fen …, 2023 - dergipark.org.tr
Ters faz sıvı kromatografi (RPLC) yöntemi asidik ve bazik fonksiyonel grup içeren bileşiklerin
iyonlaşma/protonasyon (pKa) sabitlerinin tayini için tercih edilmektedir. pKa değeri, ilaçların …

A novel approach based on capillary electrophoresis coupled to augmented multivariate curve resolution-alternating least-squares modeling for the determination of …

CM Teglia, R Brasca, L Vera-Candioti… - Chemometrics and …, 2016 - Elsevier
The determination of the dissociation constant of 2-hydroxy-4, 6-dimethylpyrimidine in
nicarbazin was carried out by means of capillary electrophoresis using a dynamic coating of …

[PDF][PDF] Determination of spectrophotometric protonation constant of cholinesterase inhibitors

YD Daldal, EÇ Demiralay, G Alsancak - International Journal of …, 2017 - dergipark.org.tr
The protonation constant (pKa) of rivastigmine, galantamine and donepezil which are
cholinesterase inhibitors used in cure of Alzheimer's disease in acetonitrile-water binary …

Measurements of Thermodynamic Acid Dissociation Constants for Three HMG-CoA Reductase Inhibitors by using RPLC and Study of Validation in Pharmaceutical …

V Canseven, EC Demiralay, Z Ustun… - Current …, 2017 - ingentaconnect.com
Present work was designed about the assignation of thermodynamic acid dissociation
constants (pKa) of pravastatin, atorvastatin, and rosuvastatin by using RPLC method. In the …

Desarrollo de estrategias analíticas basadas en técnicas cromatográficas y modelado quimiométrico para la determinación de ácido retinoico y principios activos de …

CM Teglia - 2017 - notablesdelaciencia.conicet.gov.ar
El Capítulo 1 contiene el desarrollo de métodos para la determinación de ácido retinoico en
plasma. El ácido retinoico, retinoide proveniente de la vitamina A, es responsable de varios …