A review on enzyme complexes of electron transport chain from Mycobacterium tuberculosis as promising drug targets

P Anand, Y Akhter - International journal of biological macromolecules, 2022 - Elsevier
Energy metabolism is a universal process occurring in all life forms. In Mycobacterium
tuberculosis (Mtb), energy production is carried out in two possible ways, oxidative …

Small organic molecules targeting the energy metabolism of Mycobacterium tuberculosis

M Urban, V Šlachtová, L Brulikova - European Journal of Medicinal …, 2021 - Elsevier
Causing approximately 10 million incident cases and 1.3–1.5 million deaths every year,
Mycobacterium tuberculosis remains a global health problem. The risk is further …

An intramolecular cross-talk in D29 mycobacteriophage endolysin governs the lytic cycle and phage-host population dynamics

G Nair, V Jain - Science Advances, 2024 - science.org
D29 mycobacteriophage encodes LysA endolysin, which mediates mycobacterial host cell
lysis by targeting its peptidoglycan layer, thus projecting itself as a potential therapeutic …

Construing the function of N‐terminal domain of D29 mycobacteriophage LysA endolysin in phage lytic efficiency and proliferation

R Gangakhedkar, V Jain - Molecular Microbiology, 2024 - Wiley Online Library
Endolysins produced by bacteriophages hydrolyze host cell wall peptidoglycan to release
newly assembled virions. D29 mycobacteriophage specifically infects mycobacteria …

Deciphering the role of holin in mycobacteriophage D29 physiology

VR Bavda, V Jain - Frontiers in Microbiology, 2020 - frontiersin.org
In the era of antibiotic resistance, phage therapy is gaining attention for the treatment of
pathogenic organisms such as Mycobacterium tuberculosis. The selection of phages for …

Antibacterial Mechanism of 3-Carene against the Meat Spoilage Bacterium Pseudomonas lundensis and Its Application in Pork during Refrigerated Storage

Z Tang, H Chen, M Zhang, Z Fan, Q Zhong, W Chen… - Foods, 2021 - mdpi.com
Pseudomonas lundensis is the main bacterium responsible for meat spoilage and its control
is of great significance. 3-Carene, a natural monoterpene, has been proved to possess …

Decoding phage resistance by mpr and its role in survivability of Mycobacterium smegmatis

SP Seniya, V Jain - Nucleic Acids Research, 2022 - academic.oup.com
Bacteria and bacteriophages co-evolve in a constant arms race, wherein one tries and finds
newer ways to overcome the other. Phage resistance poses a great threat to the …

Potential of Mycobacterium tuberculosis Type II NADH-Dehydrogenase in Antitubercular Drug Discovery

P Saha, M Kumar, DK Sharma - ACS Infectious Diseases, 2025 - ACS Publications
The type II NADH-dehydrogenase enzyme in Mycobacterium tuberculosis plays a critical
role in the efficient functioning of the oxidative phosphorylation pathway. It acts as the entry …

Elucidating the molecular properties and anti-mycobacterial activity of cysteine peptidase domain of D29 mycobacteriophage endolysin

R Gangakhedkar, V Jain - Journal of Virology, 2024 - journals.asm.org
Emergence of antibiotic resistance in pathogenic Mycobacterium tuberculosis (Mtb) has
elevated tuberculosis to a serious global threat, necessitating alternate solutions for its …

Understanding Metabolic Remodeling in Mycobacterium smegmatis to Overcome Energy Exigency and Reductive Stress Under Energy-Compromised State

V Patil, V Jain - Frontiers in Microbiology, 2021 - frontiersin.org
Mycobacteria such as Mycobacterium tuberculosis, the causative agent of tuberculosis that
annually kills several million people worldwide, and Mycobacterium smegmatis, the non …