ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
R Fernández-Calle, SC Konings… - Molecular …, 2022 - Springer
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
ApoE4 and connectivity-mediated spreading of tau pathology at lower amyloid levels
Importance For the Alzheimer disease (AD) therapies to effectively attenuate clinical
progression, it may be critical to intervene before the onset of amyloid-associated tau …
progression, it may be critical to intervene before the onset of amyloid-associated tau …
APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expression
The apolipoprotein E (APOE) ε4 allele is strongly linked with cerebral β-amyloidosis, but its
relationship with tauopathy is less established. We investigated the relationship between …
relationship with tauopathy is less established. We investigated the relationship between …
Sex modifies APOE ε4 dose effect on brain tau deposition in cognitively impaired individuals
S Yan, C Zheng, MD Paranjpe, Y Li, W Li, X Wang… - Brain, 2021 - academic.oup.com
Recent studies in cognitively unimpaired elderly individuals suggest that the APOE ε4 allele
exerts a dosage-dependent effect on brain tau deposition. The aim of this study was to …
exerts a dosage-dependent effect on brain tau deposition. The aim of this study was to …
[HTML][HTML] Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related …
Plasma phosphorylated tau (p-tau) and glial fibrillary acidic protein (GFAP) both reflect early
changes in Alzheimer's disease (AD) pathology. Here, we compared the biomarker levels …
changes in Alzheimer's disease (AD) pathology. Here, we compared the biomarker levels …
[HTML][HTML] Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease: Beyond the role of amyloid beta
M Lozupone, F Panza - Neural Regeneration Research, 2024 - journals.lww.com
The impact of apolipoprotein E (ApoE) isoforms on sporadic Alzheimer's disease has long
been studied; however, the influences of apolipoprotein E gene (APOE) on healthy and …
been studied; however, the influences of apolipoprotein E gene (APOE) on healthy and …
The Impact of Apolipoprotein E (APOE) Epigenetics on Aging and Sporadic Alzheimer's Disease
Simple Summary Modifications of gene expression (epigenetic alterations) have been
implicated in the pathogenesis of complex diseases, such as Alzheimer's disease (AD) …
implicated in the pathogenesis of complex diseases, such as Alzheimer's disease (AD) …
Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer's disease?
FL Vecchio, P Bisceglia, BP Imbimbo… - … in Chronic Disease, 2022 - journals.sagepub.com
Human apolipoprotein E (ApoE) is a 299-amino acid secreted glycoprotein that binds
cholesterol and phospholipids. ApoE exists as three common isoforms (ApoE2, ApoE3, and …
cholesterol and phospholipids. ApoE exists as three common isoforms (ApoE2, ApoE3, and …
Polygenic effect on tau pathology progression in Alzheimer's disease
Objective Polygenic variation accounts for a substantial portion of the risk of Alzheimer's
disease (AD), but its effect on the rate of fibrillar‐tau accumulation as a key driver of …
disease (AD), but its effect on the rate of fibrillar‐tau accumulation as a key driver of …