Oxidative stress contributes to the pathophysiology of a variety of diseases, and circulating
biomarkers of its severity remains a topic of great interest for researchers. Our peptidomic …

Identification of low-abundance, low-molecular-weight native peptides using non-tryptic
plasma has long remained an unmet challenge, leaving potential bioactive/biomarker …

The renin-angiotensin-aldosterone system plays pivotal roles in the maintenance of fluid
homeostasis and in the pathophysiology of major human diseases. However, the molecular …

Living organisms contain a variety of endogenous peptides that function as significant
regulators of many biological processes. Endogenous peptides are typically analyzed using …

The discovery of bioactive peptides is an important research target that enables the
elucidation of the pathophysiology of human diseases and provides seeds for drug …

Salusin-β is an endogenous parasympathomimetic proatherosclerotic peptide. Salusin-β
was initially predicted from bioinformatic analyses and later immunologically detected in …

Serum and plasma contain thousands of different proteins and peptides, which can provide
valuable information about the numerous processes that take place within the body …

Autoimmune mechanisms have been hypothesized to underlie a number of human
disorders in which both disease pathogenesis and diagnostic biomarkers remain poorly …

Results selection of serum tryptic peptides containing an oxidized methionine. Because Met
residues are reportedly vulnerable to oxidation in many experimental settings, we first …

生体内の内因性ペプチドには, シグナル伝達を始めとした生体機能の恒常性維持に重要な調節
因子として機能するものが多く存在する. この中には, 近年の次世代シークエンサー技術により発見 …