Autophagy is an evolutionary conserved stress survival pathway that has been shown to
play an important role in the initiation, progression, and metastasis of multiple cancers; …

Homogeneous electrochemiluminescence (HO-ECL) chemo-biosensors refer to a
configuration of ECL frameworks in which chemo-bio recognition elements are not …

Human Atg4 homologs are cysteine proteases, which play key roles in the macroautophagy/
autophagy process by cleaving Atg8 homologs for conjugation to lipid membranes and for …

Autophagy is a lysosome-dependent mechanism of intracellular degradation for maintaining
cellular homeostasis. Dysregulation of autophagy has been verified to be closely linked to a …

Cysteine protease ATG4B, a key autophagy protein, is an attractive target for colorectal
cancer therapy. However, ATG4B inhibitors with higher efficiency, safety, and clear …

Autophagy is a cell survival mechanism hijacked by advanced tumors to endure a rough
microenvironment. Late autophagy inhibitors such as (hydroxy) chloroquine have been used …

Atg4 is essential for autophagosome formation and Atg8 recycle with the function of
processing the precursor and the lipidated Atg8-family proteins. Abnormal autophagic …

Abstract Autophagy related 4B (ATG4B) which regulates autophagy by promoting the
formation of autophagosome through reversible modification of LC3, is closely related to …

Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system
required for autophagosome formation, maturation and closure. Members of the ATG4 and …

Targeting autophagy is a promising therapeutic strategy for cancer treatment. As a result, the
identification of novel autophagy inhibitors is an emerging field of research. Herein, we …