Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

S Dewanjee, S Das, AK Das, N Bhattacharjee… - European journal of …, 2018 - Elsevier
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

Diabetic peripheral neuropathy: current perspective and future directions

R Singh, L Kishore, N Kaur - Pharmacological research, 2014 - Elsevier
Diabetic neuropathy is a heterogeneous group of disorders with extremely complex
pathophysiology and affects both somatic and autonomic components of the nervous …

Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets

R Sandireddy, VG Yerra, A Areti… - International journal …, 2014 - Wiley Online Library
In Diabetes, the chronic hyperglycemia and associated complications affecting peripheral
nerves are one of the most commonly occurring microvascular complications with an overall …

Hyperglycemia, a neglected factor during cancer progression

W Duan, X Shen, J Lei, Q Xu, Y Yu, R Li… - BioMed research …, 2014 - Wiley Online Library
Recent evidence from large cohort studies suggests that there exists a higher cancer
incidence in people with type 2 diabetes (DM2). However, to date, the potential reasons for …

[HTML][HTML] Inflammation in the pathogenesis of microvascular complications in diabetes

DV Nguyen, LC Shaw, MB Grant - Frontiers in endocrinology, 2012 - frontiersin.org
Diabetes and hyperglycemia create a proinflammatory microenvironment that progresses to
microvascular complications such as nephropathy, retinopathy, and neuropathy. Diet …

Molecular pathways of NF-ĸB and NLRP3 inflammasome as potential targets in the treatment of inflammation in diabetic wounds: A review

HX Teh, SJ Phang, ML Looi, UR Kuppusamy… - Life Sciences, 2023 - Elsevier
Diabetic wounds are slow healing wounds characterized by disordered healing processes
and frequently take longer than three months to heal. One of the defining characteristics of …

Pathogenesis of diabetic neuropathy: focus on neurovascular mechanisms

PS Van Dam, MA Cotter, B Bravenboer… - European journal of …, 2013 - Elsevier
Neuropathies of the peripheral and autonomic nervous systems affect up to half of all people
with diabetes, and are major risk factors for foot ulceration and amputation. The aetiology is …

[HTML][HTML] Metaflammation in glucolipid metabolic disorders: Pathogenesis and treatment

P Xiong, F Zhang, F Liu, J Zhao, X Huang, D Luo… - Biomedicine & …, 2023 - Elsevier
The public health issue of glucolipid metabolic disorders (GLMD) has grown significantly,
posing a grave threat to human wellness. Its prevalence is rising yearly and tends to affect …

Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs

MJ Lapponi, A Carestia, VI Landoni… - … of Pharmacology and …, 2013 - ASPET
The formation of neutrophil extracellular traps (NETs) is a newly described phenomenon that
increases the bacteria-killing ability and the inflammatory response of neutrophils. Because …

SIRT1 activation by polydatin alleviates oxidative damage and elevates mitochondrial biogenesis in experimental diabetic neuropathy

P Bheereddy, VG Yerra, AK Kalvala… - Cellular and molecular …, 2021 - Springer
Mitochondrial dysfunction has been implicated as a one of the major factors linked to the
development of painful diabetic neuropathy (DN). Several studies have demonstrated that …