Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …

Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely
expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored …

The greatest risk factor for developing carcinoma of the prostate is advanced age. Potential
molecular and physiologic contributors to the frequency of cancer occurrence in older …

Heparan sulfate proteoglycans (HSPGs) play diverse roles in cell recognition, growth, and
adhesion. In vitro studies suggest that cell-surface HSPGs act as coreceptors for heparin …

Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR).
AREG plays a central role in mammary gland development and branching morphogenesis …

We determined whether down-regulation of the epidermal growth factor-receptor (EGF-R)
signaling pathway by oral administration of a novel EGF-R tyrosine kinase inhibitor (PKI166) …

To investigate the relationship between DNA hypomethylation and gene overexpression in
pancreatic cancer, we analyzed the methylation status of a subset of 18 genes previously …

Human pancreatic cancers overexpress a number of important tyrosine growth factor
receptors and their ligands. These include the epidermal growth factor (EGF) receptor …

Pancreatic cancer is the most lethal abdominal malignancy due to its aggressive growth and
rapid development of distant metastases, thus making treatment extremely difficult …

Urokinase plasminogen activator (uPA) is a serine proteinase that has been suggested to
play an important role in cancer invasion and metastasis. It binds to a specific membrane …