Patients with advanced prostate cancer often develop bone metastases, leading to bone
pain, skeletal fracture, and increased mortality. Bone provides a hospitable …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Early developmental perturbations have been linked to adult-onset prostate pathology,
including excessive exposure to estrogenic compounds; however, the molecular basis for …

Cholesterol is essential for cell function and viability. It is a component of the plasma
membrane and lipid rafts and is a precursor for bile acids, steroid hormones, and Vitamin D …

An antibody, GC-17, thoroughly characterized for its specificity for estrogen receptor-β (ER-
β), was used to immunolocalize the receptor in histologically normal prostate, prostatic …

Early work on the hormonal basis of prostate cancer focused on the role of androgens, but
more recently estrogens have been implicated as potential agents in the development and …

In normal rats and mice, immunostaining with specific antibodies revealed that nuclei of
most prostatic epithelial cells harbor estrogen receptor β (ERβ). In rat ventral prostate, 530 …

OBJECTIVES: Both obesity and prostate cancer (PCa) are epidemic in Western society.
Although initial epidemiological data appeared conflicting, recent studies have clarified the …

The aim of the current study is to demonstrate normal and malignant prostatic epithelial cells
(PrECs) as targets for receptor-mediated estrogenic and antiestrogenic action. Using an …

Carcinoma of the prostate is the most frequently diagnosed malignancy and the second
leading cause of death as a result of cancer in men in the United States and in many other …