The impact of protein corona on the biological behavior of targeting nanomedicines
For successful translation of targeting nanomedicines from bench to bedside, it is vital to
address their most common drawbacks namely rapid clearance and off-target accumulation …
address their most common drawbacks namely rapid clearance and off-target accumulation …
Understanding the nanoparticle–protein corona complexes using computational and experimental methods
Nanoparticles (NP) have capability to adsorb proteins from biological fluids and form protein
layer, which is called protein corona. As the cell sees corona coated NPs, the protein corona …
layer, which is called protein corona. As the cell sees corona coated NPs, the protein corona …
Tailoring the component of protein corona via simple chemistry
Control over the protein corona of nanomaterials allows them to function better. Here, by
taking graphene/gold as examples, we comprehensively assessed the association of …
taking graphene/gold as examples, we comprehensively assessed the association of …
Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano–bio interactions
Deep interrogation of plasma proteins on a large scale is a challenge due to the number and
concentration of proteins, which span a dynamic range of over 10 orders of magnitude …
concentration of proteins, which span a dynamic range of over 10 orders of magnitude …
One low-dose exposure of gold nanoparticles induces long-term changes in human cells
P Falagan-Lotsch, EM Grzincic… - Proceedings of the …, 2016 - National Acad Sciences
We report the in vitro long-term (20 wk) changes in cells exposed to well-characterized gold
nanoparticles (Au NPs) with varying shapes and surface coatings under both chronic …
nanoparticles (Au NPs) with varying shapes and surface coatings under both chronic …
Regulating protein corona formation and dynamic protein exchange by controlling nanoparticle hydrophobicity
Q Yu, L Zhao, C Guo, B Yan, G Su - Frontiers in bioengineering and …, 2020 - frontiersin.org
Physiochemical properties of engineered nanoparticles (NPs) play a vital role in nano-bio
interactions, which are critical for nanotoxicity and nanomedicine research. To understand …
interactions, which are critical for nanotoxicity and nanomedicine research. To understand …
Bovine serum albumin interacts with silver nanoparticles with a “side-on” or “end on” conformation
As the nanoparticles (NPs) enter into the biological interface, they have to encounter
immediate and first exposure to many proteins of different concentrations. The …
immediate and first exposure to many proteins of different concentrations. The …
Effect of dopamine-functionalization, charge and pH on protein corona formation around TiO 2 nanoparticles
P Siani, C Di Valentin - Nanoscale, 2022 - pubs.rsc.org
Inorganic nanoparticles (NPs) are gaining increasing attention in nanomedicine because of
their stimuli responsiveness, which allows combining therapy with diagnosis. However, little …
their stimuli responsiveness, which allows combining therapy with diagnosis. However, little …
Protein corona formed from different blood plasma proteins affects the colloidal stability of nanoparticles differently
Significant progress in the characterization of protein corona has been made. However,
insights on how the corona affects the aggregation of nanoparticles (NPs) and consequent …
insights on how the corona affects the aggregation of nanoparticles (NPs) and consequent …
Coarse-grained model of adsorption of blood plasma proteins onto nanoparticles
H Lopez, V Lobaskin - The Journal of chemical physics, 2015 - pubs.aip.org
We present a coarse-grained model for evaluation of interactions of globular proteins with
nanoparticles (NPs). The protein molecules are represented by one bead per aminoacid …
nanoparticles (NPs). The protein molecules are represented by one bead per aminoacid …