Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

Adult differentiated cells can be reprogrammed into pluripotent stem cells or lineage-
restricted proliferating precursors in culture; however, this has not been demonstrated in …

Spinal cord injury (SCI) leads to irreversible neuronal loss and glial scar formation, which
ultimately result in persistent neurological dysfunction. Cellular regeneration could be an …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

Both major depressive disorder and bipolar disorder are the subject of a voluminous
imaging and genetics literature. Here, we attempt a comprehensive review of MRI and …

It has become apparent that chromatin modification plays a critical role in the regulation of
cell-type-specific gene expression. Here, we show that an inhibitor of histone deacetylase …

The neurogenesis hypothesis of depression posits (1) that neurogenesis in the subgranular
zone of the dentate gyrus is regulated negatively by stressful experiences and positively by …

New neurons are generated in the adult hippocampus of many species including rodents,
monkeys, and humans. Conditions associated with major depression, such as social stress …

Epileptogenesis refers to a process in which an initial brain-damaging insult triggers a
cascade of molecular and cellular changes that eventually lead to the occurrence of …