Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various
reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant …

Apoptosis may contribute to a significant proportion of neuron death following acute brain
ischemia (ABI), but the underlying mechanisms are still not fully understood. Brain ischemia …

Hyperlipidemia is a well-established risk factor for developing cardiovascular disease
(CVD). The recent American College of Cardiology and American Heart Association …

Importance There is limited information about the effect of erythropoietin or a high
hemoglobin transfusion threshold after a traumatic brain injury. Objective To compare the …

In addition to its well-established neurotrophic action, brain-derived neurotrophic factor
(BDNF) also possesses other neuroprotective effects including anti-apoptosis, anti …

Data from the Women's Health Study show that serum levels of growth-differentiation factor-
15 (GDF-15), a distant member of the transforming growth factor-β superfamily, are an …

BACKGROUND CONTEXT: The past three decades have witnessed increasing interest in
strategies to improve neurologic function after spinal cord injury. As progress is made in our …

Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian
brain. In clinical settings, recombinant EPO treatment has revealed a remarkable …

Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to
the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical …

Neuroprotection and brain repair in patients after acute brain damage are still major
unfulfilled medical needs. Pharmacological treatments are either ineffective or confounded …