Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

The canonical mechanism of organophosphate (OP) neurotoxicity is the inhibition of
acetylcholinesterase (AChE). However, multiple lines of evidence suggest that mechanisms …

Organophosphorus compounds (OP) are a constant problem, both in the military and in the
civilian field, not only in the form of acute poisoning but also for their long-lasting …

Acute intoxication with organophosphate (OP) cholinesterase inhibitors poses a significant
public health risk. While currently approved medical countermeasures can improve survival …

Status epilepticus (SE) remains a significant cause of morbidity and mortality and often is
refractory to standard first‐line treatments. A rapid loss of synaptic inhibition and …

Exposure to high levels of a cholinesterase inhibiting organophosphorus (OP) agent often
results in seizures that progress to status epilepticus (SE). Survivors of OP-induced SE often …

Organophosphate pesticides and nerve agents (OPs), are characterized by cholinesterase
inhibition. In addition to severe peripheral symptoms, high doses of OPs can lead to seizures …

Recent experimental evidence suggests combined treatment with midazolam and
allopregnanolone is more effective than midazolam alone in terminating seizures triggered …

Background Whole brain delineation (WBD) is utilized in neuroimaging analysis for data
preprocessing and deriving whole brain image metrics. Current automated WBD techniques …

Tetramethylenedisulfotetramine (TETS), a noncompetitive GABAA receptor antagonist, is a
potent, highly lethal convulsant that is considered to be a chemical threat agent. Here, we …