Cells must be able to cope with the challenge of folding newly synthesized proteins and
refolding those that have become misfolded in the context of a crowded cytosol. One such …

Posttranslational modifications are covalent changes made to proteins that typically alter the
function or location of the protein. AMPylation is an emerging posttranslational modification …

Cancer evolves through a multistep process that occurs by the temporal accumulation of
genetic mutations. Tumor-derived exosomes are emerging contributors to tumorigenesis. To …

The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a
reversible inactivating post-translational modification. Both BiP AMPylation and …

Fic domain-containing AMP transferases (fic AMPylases) are conserved enzymes that
catalyze the covalent transfer of AMP to proteins. This posttranslational modification …

Post-translational protein modifications are essential for the spatio-temporal regulation of
protein function. In this study, we examine how the activity of the Caenorhabditis elegans …

During homeostasis, the endoplasmic reticulum (ER) maintains productive transmembrane
and secretory protein folding that is vital for proper cellular function. The ER-resident HSP70 …

Fic domain-containing AMP transferases (fic AMPylases) are conserved enzymes that
catalyze the covalent transfer of AMP to proteins. This post-translational modification …

Protein AMPylation has emerged as a posttranslational protein modification regulating
cellular proteostasis. AMPylation is conferred by Fic AMPylases, which catalyze the covalent …

Cancer evolves through a multistep process that occurs by the temporal accumulation of
genetic mutations mediated by intracellular and extracellular cues. We observe that …