Do post-translational modifications influence protein aggregation in neurodegenerative diseases: a systematic review
LN Schaffert, WG Carter - Brain sciences, 2020 - mdpi.com
The accumulation of abnormal protein aggregates represents a universal hallmark of
neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate …
neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate …
Post-translational modifications: regulators of neurodegenerative proteinopathies
One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …
Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in
over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) …
over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) …
Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer's disease-like symptoms in animal model
GK Viswanathan, D Shwartz, Y Losev, E Arad… - Cellular and Molecular …, 2020 - Springer
Neurofibrillary tangles of the Tau protein and plaques of the amyloid β peptide are hallmarks
of Alzheimer's disease (AD), which is characterized by the conversion of monomeric …
of Alzheimer's disease (AD), which is characterized by the conversion of monomeric …
The Hidden Players: Shedding Light on the Significance of Post-Translational Modifications and miRNAs in Alzheimer's Disease Development
Alzheimer's disease (AD) is the most prevalent, expensive, lethal, and burdening
neurodegenerative disease of this century. The initial stages of this disease are …
neurodegenerative disease of this century. The initial stages of this disease are …
Aggregated Tau-PHF6 (VQIVYK) potentiates NLRP3 inflammasome expression and autophagy in human microglial cells
Intra-neuronal misfolding of monomeric tau protein to toxic β-sheet rich neurofibrillary
tangles is a hallmark of Alzheimer's disease (AD). Tau pathology correlates not only with …
tangles is a hallmark of Alzheimer's disease (AD). Tau pathology correlates not only with …
Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation
S Zavadskiy, S Sologova, N Moldogazieva - Biochimie, 2022 - Elsevier
The concept of oxidative distress had arisen from the assessment of cellular response to
high concentrations of reactive species that result from an imbalance between oxidants and …
high concentrations of reactive species that result from an imbalance between oxidants and …
Identification of Aggregation Mechanism of Acetylated PHF6* and PHF6 Tau Peptides Based on Molecular Dynamics Simulations and Markov State Modeling
The microtubule-associated protein tau (MAPT) has a critical role in the development and
preservation of the nervous system. However, tau's dysfunction and accumulation in the …
preservation of the nervous system. However, tau's dysfunction and accumulation in the …
Exploring the Aggregation Propensity of PHF6 Peptide Segments of the Tau Protein Using Ion Mobility Mass Spectrometry Techniques
I Stroganova, H Willenberg, T Tente… - Analytical …, 2024 - ACS Publications
Peptide and protein aggregation involves the formation of oligomeric species, but the
complex interplay between oligomers of different conformations and sizes complicates their …
complex interplay between oligomers of different conformations and sizes complicates their …
Naphthoquinone tryptophan hybrids: A promising small molecule scaffold for mitigating aggregation of amyloidogenic proteins and peptides
A current challenge faced by researchers is the lack of disease-modifying therapeutics for
amyloid formation that is associated with several human diseases. Although the monomeric …
amyloid formation that is associated with several human diseases. Although the monomeric …