This review is intended to cover the applications of olefin metathesis, with its variations, to
the synthesis and manipulation of peptides and peptidomimetics. The examples presented …

An efficient yttrium‐catalyzed intramolecular hydroalkoxylation/Claisen rearrangement
sequence has been achieved, thus enabling facile access to a diverse array of valuable …

Many drugs suffer from an extensive first-pass metabolism leading to drug inactivation
and/or production of toxic metabolites, which makes them attractive targets for prodrug …

The synthesis of medium-sized lactams is a great challenge because of the unfavorable
transannular interactions and entropic barriers in the transition state. We have developed a …

A short entry to substituted azocanes by a Rh-catalyzed cycloaddition–fragmentation
process is described. Specifically, exposure of diverse N-cyclopropylacrylamides to …

A novel palladium-catalyzed intramolecular hydroaminocarbonylation of aminoalkynes has
been developed. This direct and operationally simple protocol provides a rapid and reliable …

The iodine-catalyzed catalytic formal [3+ 3+ 1] cycloaddition for the preparation of a seven-
membered O-heterocyclic ring is presented, which is an achievement of methyl and carbonyl …

Peptidomimetic inhibitors of the hepatitis C NS3 protease often exhibit poor
biopharmaceutical properties. Structure modification of a substrate-based tripeptide into a β …

Authored by two internationally recognized experts with an excellent track record, this much-
needed reference summarizes latest research in the rapidly developing field of …

We present an E-selective ring-closing metathesis reaction in α-helical stapled peptides at
positions i and i+ 4. The use of two chiral carbocyclic α, α-disubstituted α-amino acids,(1 S, 3 …