Intrinsically disordered proteins (IDPs) and multidomain proteins with flexible linkers show a
high level of structural heterogeneity and are best described by ensembles consisting of …

Many proteins require different structural states or conformations for function, and
intrinsically disordered proteins, ie proteins without stable three-dimensional structure, are …

Eukaryotic gene regulation and pre-mRNA transcription depend on the carboxy-terminal
domain (CTD) of RNA polymerase (Pol) II. Due to its highly repetitive, intrinsically disordered …

Ferroptosis, an iron-dependent cell death, plays a crucial role in the pathology of
Alzheimer's disease (AD). Several characteristics of AD, including excessive iron …

The power of structural information for informing biological mechanisms is clear for stable
folded macromolecules, but similar structure–function insight is more difficult to obtain for …

Disordered proteins and nucleic acids play key roles in cellular function and disease. Here,
we review recent advances in the computational exploration of the conformational dynamics …

Cryogenic electron microscopy has revealed unprecedented molecular insight into the
conformations of β-sheet-rich protein amyloids linked to neurodegenerative diseases. It …

Butyrylcholinesterase (BChE) is one of the most frequently implicated enzymes in the
advanced stage of Alzheimer's disease (AD). As part of our endeavors to develop new drug …

Intrinsically disordered proteins (IDPs) and regions (IDRs) have emerged as key players
across many biological functions and diseases. Differently from structured proteins …

Single-stranded RNA (ssRNA) plays a major role in the flow of genetic information–most
notably, in the form of messenger RNA (mRNA)–and in the regulation of biological …