Lipid-lowering therapy is an important tool for the treatment of lipid metabolic diseases,
which are increasing in prevalence. However, the failure of conventional lipid-lowering …

NPC1L1 is a crucial protein involved in sterol lipid absorption and has been shown to play
an important role in intestinal cholesterol absorption. Hypercholesterolemia is a significant …

As endogenous courier vesicles, exosomes play crucial roles in macromolecule
transmission and intercellular communication. Therefore, exosomes have drawn increasing …

Background: The risk of cardiovascular disease in type 1 diabetes remains extremely high,
despite marked advances in blood glucose control and even the widespread use of …

Epidemiological data have demonstrated a significant association between the presence of
type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic …

Elevated cholesterol significantly increases the risk of developing atherosclerosis and
coronary heart disease. The key to treating hypercholesterolemia is lowering plasma …

Atherosclerosis (AS) is characterized by dyslipidemia and chronic inflammation. In the high-
fat environment, the lipid metabolism of dendritic cells (DCs) is abnormal, which leads to …

Zearalenone is an estrogenic mycotoxin produced by a variety of Fusarium fungi. There is
evidence that exposure to zearalenone can cause intrauterine growth restriction, but little is …

Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-
BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell …

How do cells coordinate the diverse elements that regulate their cholesterol homeostasis?
Our model postulates that membrane cholesterol forms simple complexes with bilayer …