Introduction Clear cell sarcoma (CCS) is an ultrarare soft tissue sarcoma (STS) with a poor
prognosis due to its propensity to metastasize and its low chemosensitivity. The standard …

The histopathological diagnosis of melanoma is fraught with potential pitfalls. In the setting
of cutaneous metastatic melanoma, it is important to recognise the various histological …

To elucidate the mechanisms underlying the divergent clinicopathologic spectrum of
EWSR1/FUS:: CREB translocation-associated tumors, we performed a comprehensive …

Transcription dysregulation is common in sarcomas driven by oncogenic transcription
factors. Clear cell sarcoma of soft tissue (CCSST) is a rare sarcoma with poor prognosis …

Bone and soft tissue tumors are generally classified into complex karyotype sarcomas
versus those with recurrent genetic alterations, often in the form of gene fusions. In this …

Purpose Intracytoplasmic melanin pigment is a characteristic of clear cell sarcoma (CCS),
which is a particularly deadly type of soft-tissue sarcoma.[18F]-N-(2-(diethylamino) ethyl)-5 …

Survival for children with cancer has primarily improved over the past decades due to
refinements in surgery, radiation and chemotherapy. Although these general therapies are …

EWSR1 fusions are highly promiscuous and are associated with unique malignancies,
clinical phenotypes, and molecular subtypes. However, rare fusion partners (RFP) of …

We describe exciting recent advances in fusion-driven sarcoma etiology, from an
epigenetics perspective. By exploring the current state of the field, we identify and describe …

Background Synovial sarcoma (SS) is a rare soft-tissue cancer. Existing literature
encompasses Surveillance, Epidemiology, and End Results (SEER) data-based research …