A guideline on the molecular ecosystem regulating ferroptosis

E Dai, X Chen, A Linkermann, X Jiang, R Kang… - Nature cell …, 2024 - nature.com
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions

G Lei, L Zhuang, B Gan - Cancer cell, 2024 - cell.com
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

GDF15 is a major determinant of ketogenic diet-induced weight loss

JF Lu, MQ Zhu, B Xia, NN Zhang, XP Liu, H Liu… - Cell Metabolism, 2023 - cell.com
A ketogenic diet (KD) has been promoted as an obesity management diet, yet its underlying
mechanism remains elusive. Here we show that KD reduces energy intake and body weight …

Muscle wasting: emerging pathways and potential drug targets

A Domaniku, SN Bilgic, S Kir - Trends in Pharmacological Sciences, 2023 - cell.com
Muscle wasting is a serious comorbidity associated with many disorders, including cancer,
kidney disease, heart failure, and aging. Progressive loss of skeletal muscle mass …

Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

YL Xiao, Y Gong, YJ Qi, ZM Shao… - Signal Transduction and …, 2024 - nature.com
Diet, serving as a vital source of nutrients, exerts a profound influence on human health and
disease progression. Recently, dietary interventions have emerged as promising adjunctive …

[HTML][HTML] Dietary approaches for exploiting metabolic vulnerabilities in cancer

O Menyhárt, B Győrffy - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Renewed interest in tumor metabolism sparked an enthusiasm for dietary interventions to
prevent and treat cancer. Changes in diet impact circulating nutrient levels in the plasma …

Ferroptotic therapy in cancer: benefits, side effects, and risks

J Diao, Y Jia, E Dai, J Liu, R Kang, D Tang, L Han… - Molecular Cancer, 2024 - Springer
Ferroptosis is a type of regulated cell death characterized by iron accumulation and
uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular …

Interactions between diet and gut microbiota in cancer

G Nakatsu, N Andreeva, MH MacDonald… - Nature Microbiology, 2024 - nature.com
Dietary patterns and specific dietary components, in concert with the gut microbiota, can
jointly shape susceptibility, resistance and therapeutic response to cancer. Which diet …

β‐Hydroxybutyrate enhances chondrocyte mitophagy and reduces cartilage degeneration in osteoarthritis via the HCAR2/AMPK/PINK1/Parkin pathway

H Zhuang, X Ren, Y Zhang, H Li, P Zhou - Aging Cell, 2024 - Wiley Online Library
Osteoarthritis (OA) is widely recognized as the prevailing joint disease associated with
aging. The ketogenic diet (KD) has been postulated to impede the advancement of various …

A waste product's unexpected role in wasting

JD Sanford, MD Goncalves - Nature Metabolism, 2024 - nature.com
A waste product’s unexpected role in wasting | Nature Metabolism Skip to main content Thank
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