TGF-β signaling from receptors to Smads

A Hata, YG Chen - Cold Spring Harbor perspectives in …, 2016 - cshperspectives.cshlp.org
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …

Diversifying microRNA sequence and function

SL Ameres, PD Zamore - Nature reviews Molecular cell biology, 2013 - nature.com
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …

The widespread regulation of microRNA biogenesis, function and decay

J Krol, I Loedige, W Filipowicz - Nature reviews genetics, 2010 - nature.com
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression
that are∼ 21 nucleotides in length and control many developmental and cellular processes …

Aberrant regulation and function of microRNAs in cancer

BD Adams, AL Kasinski, FJ Slack - Current Biology, 2014 - cell.com
Malignant neoplasms are consistently among the top four leading causes of death in all age
groups in the United States, despite a concerted effort toward developing novel therapeutic …

MicroRNAs and epigenetics

F Sato, S Tsuchiya, SJ Meltzer, K Shimizu - The FEBS journal, 2011 - Wiley Online Library
MicroRNAs (miRNAs) comprise species of short noncoding RNA that regulate gene
expression post‐transcriptionally. Recent studies have demonstrated that epigenetic …

MicroRNA biogenesis: regulating the regulators

EF Finnegan, AE Pasquinelli - Critical reviews in biochemistry and …, 2013 - Taylor & Francis
MicroRNAs (miRNAs) function as 21–24 nucleotide guide RNAs that use partial base-
pairing to recognize target messenger RNAs and repress their expression. As a large …

Inhibition and role of let-7d in idiopathic pulmonary fibrosis

KV Pandit, D Corcoran, H Yousef… - American journal of …, 2010 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually lethal
fibrotic lung disease characterized by profound changes in epithelial cell phenotype and …

miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma

M Furuta, K Kozaki, S Tanaka, S Arii, I Imoto… - …, 2010 - academic.oup.com
MicroRNAs (miRNAs) are a class of small non-coding RNAs that, in general, negatively
regulate gene expression. They have been identified in various tumor types, showing that …

Hypoxia: a master regulator of microRNA biogenesis and activity

S Nallamshetty, SY Chan, J Loscalzo - Free Radical Biology and Medicine, 2013 - Elsevier
Hypoxia, or low oxygen tension, is a unique environmental stress that induces global
changes in a complex regulatory network of transcription factors and signaling proteins to …

Mechanisms of control of microRNA biogenesis

BN Davis-Dusenbery, A Hata - The journal of biochemistry, 2010 - academic.oup.com
MicroRNAs (miRNAs) are a class of∼ 22 nt non-coding RNAs that control diverse biological
functions in animals, plants and unicellular eukaryotes by promoting degradation or …